Resume

Manuel Martínez-Lavín MD.

Internist and Rheumatologist.

Research interests:

Cardiovascular involvement of rheumatic diseases and viceversa.

Addresses

Instituto Nacional de Cardiologia Ignacio Chavez
Juan Badiano # 1
14080 Mexico D.F. MEXICO
Phone 55732911 ext 1175
Fax 55730994

Private Office:
Medica Sur
Puente de Piedra 150
14050 Mexico D.F. MEXICO
Phones 56064714 56065433
Fax 56064714

E-mail: mmlavin@infosel.net.mx
http://www.martinez-lavin.com/

Professional education

Medical School
Universidad Nacional Autonoma de Mexico.(UNAM) (1965-1971)

Postgraduate training
Internal Medicine. St. Louis University. St. Louis Missouri USA (1972-1975).
Rheumatology. Scripps Clinic. La Jolla California USA. (1975-1977)

Degrees and Qualifications

Medical Doctor Degree. National Autonomous University of Mexico: 1971
License to practice Medicine in the state of Missouri USA. 1974
Appointed as Chief Resident of Internal Medicine. St. Louis City Hospital USA. 1975
Internal Medicine Diploma. St. Louis University USA. 1975
Internal Medicine Certificate. American Board of Internal Medicine. 1975
License to practice Medicine in the State of California. 1975
Rheumatology Diploma. Scripps Clinic USA. 1977
Rheumatology Certificate. American Board of Internal Medicine. 1978
Rheumatology Certificate. Mexican Council of Rheumatology. 1978
Internal Medicine Certificate. Mexican Council of Internal Medicine. 1994

Academic Career

Clinical Researcher. Rheumatology Department, National Cardiology Institute of Mexico. 1977 to date.
Chief Rheumatology Department at the National Cardiology Institute. 1983 to date.
Assistant Professor of the Rheumatology. National Autonomous University of Mexico. 1980-1983.
Full Professor of the Rheumatology. National Autonomous University of Mexico. 1983 to date.
Titular Researcher. National Health Institutes. (level C) 1989 to date.
National Investigator. National Investigation System. 1990 to date.

Academic Associations

American College of Physicians. 1975 to date
American College of Rheumatology. 1977 to date
Association of Interns and Scholarship Holders at the National Cardiology Institute of Mexico. 1978 to date
Mexican Society of Rheumatology. 1978 to date
Mexican Society of Cardiology. 1979 to date
National Academy of Medicine. 1990 to date

Directive positions in academic societies

Mexican Rheumatology Council. President 1984-1985
Mexican Rheumatology Society. President 1987-1988
National Academy of Medicine. Secretary. 1994

Editorial board memberships

1. Archivos del Instituto de Cardiologia de Mexico. 1980 to date
2. Revista Mexicana de Reumatología 1987 to date
3. Journal of Clinical Rheumatology 1997 to date
4. Clinical Rheumatology 2002 to date

Publications

1. Lisker R, Hernández A, Martínez-Lavín M, Mutchinik O, Armas C, Reyes P, Robles Gil J. Geroderma osteodysplastica hereditaria: Report of three affected brothers and literature review. AM J Med Gen 1979:3;389-395

2. Martínez-Lavín M, Vaughan JH, Tan EM. Autoantibodies and the spectrum of Sjogren’s syndrome. Ann Intern Med 1979:92;185-190

3. Reyes PA, Martínez-Lavin M. Behcet’s syndrome: report of three cases and recent literature review. Gac Med Mex 1979:115;573-577

4. Pineda E, Martínez-Lavín M. Hypertrophic osteoarthropathy in cyanotic congenital heart disease. Report of two cases. Arch Inst Cardiol Mex 1980:50;151-155

5. Martínez-Lavín M, Vaughan JH, Holman KI, Smyth C. A comparison of naproxen, indomethacin, and aspirin in osteoarthritis. J Rheumatol 1980:7;711-716

6. Gobaira J, Bobadilla M, Martínez-Lavín M. Oral manifestations of rheumatic diseases. Acta Med Dom* 1980:2;33-36

7. Martínez-Lavín M, Bobadilla M, Casanova J, Attié F, Martínez M. Hypertrophic osteoarthropathy in cyanotic congenital heart disease: its prevalence and relationship to bypass of the lung. Arthritis Rheum 1982:25;1186-1193

8. Guadalajara JF, Martínez-Lavín M, Zusserman M, Solines L, Casanova JM, Reyes P. The heart in scleroderma phono-echocardiographic study. Arch Inst Cardiol Mex 1983:53;27-32

9. Martínez-Lavín M. Cardiopulmonary involvement in rheumatic diseases. Arch Inst Cardiol Mex 1983:53;247-251

10. Martínez-Lavín M, Buendía A, Delgado E, Reyes P, Amigo MC, Sabanés J, Zghaib A, Attié F, Salinas L. A familial syndrome of pericarditis, arthritis and camptodactyly. N Engl J Med 1983:309;224-225

11. Martínez-Lavín M, Amigo MC, Castillejos G, Padilla L, Vintimilla F. Coexistent gout and hypertrophic osteoarthropathy in patients with cyanotic heart disease. J. Rheumatol 1984;11:832-834

12. Pop G, Romero L, Bialostozky D, Medrano G, Martínez-Lavín M. Cardiac involvement in ankylosing spondylitis. Arch Inst Cardiol Mex 1985:55;63-67

13. Pineda C, Weisman M, Guerra A, Resnick D, Martínez-Lavín M The skeletal manifestations of clubbing: A study in patients with cyanotic heart disease and hypertrophic osteoarthropathy. Sem Arthritis Rheum 1985:14;263-267

14. Martínez-Lavín M, Castillejos G. Digital clubbing and hypertrophic osteoarthropathy. Arch Inst Cardiol Mex 1985:55;415-419

15. Martínez-Lavín M. Monoarthritis. Rev Mex Reumatol* 1986:1:34-36

16. Nava-Zavala A, Amigo MC, Martínez-Lavín M. The heart in disseminated lupus erythematosus Princ Cardiol* 1986:2;53-68

17. Martínez-Lavín M, Castillejos G. Ferritin and prostaglandins in hypertrophic osteoarthropathy (letter). J Rheumatol 1986: 13;834-836

18. Martínez-Lavín M: Collagen and collagenosis. Rev Mex Reumatol* 1987:2,89-90

19. Amigo MC, Gómez T, Martínez-Lavín M. Oral aurotherapy in juvenil rheumatoid arthritis. Rev Mex Reumatol*.

20. Castillejos G, Martínez-Lavin M. Discrepancy between arterial ferritin levels and the presence of digital clubbing. Clin Rheumatol 1987 (2) 297-298

21. Pineda C, Martínez-Lavín M, Goobar J, Sartoris D, Clopton P, Resnick D. Periostitis in hypertrophic osteoarthropathy. Am J Roentgenol AJR 1987:148;773-778

22. Cajigas JC, Amigo MC, Pineda C, Herrera R, Sánchez-Torres G, Martínez-Lavín M. Association between Takayasu’s arteritis and cutaneous polyarteritis nodosa. Am J Med 1987:82;382-384.

23. Martínez-Lavín M. Speech of the President of the Mexican Society of Rheumatology (1987-1988). Rev Mex Reumatol* 1988:3;51-52

24. Martínez-Lavín M. Digital clubbing and hypertrophic osteoarthropathy: a unifying hypothesis. J Rheumatol 1987:14;6-8

25. Martínez-Lavín M, Pineda C, Vázquez-Abad D. Platelets and clubbing (letter). Lancet 1988:I;761.

26. Martínez-Lavín M, Pineda C, Valdéz T, Cajigas JC, Weisman M, Gerber N, Steigler D: Primary hypertrophic osteoarthropathy. Sem Arthritis Rheum 1988:17;156-162

27. Martínez-Lavín M. Rheumatic fever in Mexico. New challenges, new strategies. Arch Inst Cardiol Mex 1989:59;349-351

28. Martínez-Lavín M. Hypertrophic osteopathy, new perspectives. Rev Esp Reumatol* 1989:16;79-80

29. García A, Martínez-Lavín M. Hypertrophic osteoarthropathy of the animals. Rev Mex Reumatol* 1989:4,146-148

30. Vázquez-Abad D, Pineda C, Martínez-Lavín M. Digital clubbing: a numerical assessment of the deformity. J Rheumatol 1989:16;518-520

31. Pineda C, Fonseca C, Martínez-Lavín M. The spectrum of soft tissue and skeletal abnormalities of hypertrophic osteoarthropathy. J. Rheumatol 1989:16,518-520

32. Martínez-Lavín M, Pineda C. Digital clubbing (letter). Lancet 1990:1;1444

33. Martínez-Lavín M. Naproxen indomethacin and aspirin in the treatment of osteoarthritis. A comparison using a modification of the double-blind crossover study. Clin Therap* 1991:13;suppl A. 16-19

34. Vázquez-Abad D, Martínez-Lavín M. Macrothrombocytes in the peripheral circulation of patients with cardiogenic hypertrophic osteoarthropathy. Clin Exp Rheumatol 1991:9;59-62

35. Martínez-Lavín M: The etiology of digital clubbing. Gac Med Mex 1991;127:221-225

36. Morales E, Pineda C, Martínez-Lavín M. Takayasu’s arteritis in children. J Rheumatol 1991:18;1081-1084

37. Martínez-Lavín M Recent findings in hypertrophic osteoarthropathy. Contemp Intern Med* 1992:75-85

38. Matucci-Cerinic M, Martínez-Lavín M, Rojo F, Fonseca C, Kahaleh B. von Willebrand factor antigen in hypertrophic osteoarthropathy. J Rheumatol 1992:19;765-767

39. Martínez-Lavín M. Cardiogenic hypertrophic osteoarthropathy. Clin Exp Rheumatol 1992:10;S-7-22

40. Martínez-Lavín M. Pathogenesis of hypertrophic osteoarthropathy. Clin Exp Rheumatol 1992:10;S-7;49-50

41. Martínez-Lavín M, Pineda C, Navarro C, Buendía A, Zabal C. Primary hypertrophic osteoarthropathy; another heritable disorder associated to patent ductus arteriosus. Pediatric Cardiol 1993:14;181-182

42. Amigo MC, Martínez-Lavín M, Reyes PA. Acute rheumatic fever. Rheum Dis Clin North Am 1993:19;333-350

43. Martínez-Lavín M, Matucci-Cerinic M, Jajic I, Pineda C. Workshop report. Hypertrophic osteoarthropathy, a consensus on its definition, classification, assessment and diagnostic criteria. J Rheumatol 1993:20;1386-1387

44. Pineda C, Arana B, Martínez-Lavín M, Dábague J. Frozen shoulder triggered by cardiac catheterization via the brachial artery. Am J Med 1994:96;90-91

45. Mondragón-Ramírez G, Bochicchio T, García Torres R, Amigo MC, Martínez-Lavín M, Reyes P, Herrera-Acosta J. Recurrent renal thrombotic angiopathy after kidney transplantation in two patients with primary antiphospholipid syndrome (PAPS). Clin Transp 1994:8;93-96

46. Martínez-Lavín M: Elucidation of digital clubbing may help in understanding the pathogenesis of pulmonary hypertension associated with congenital heart defects. Cardiol Young 1994:4;228-231

47. Martínez-Lavín M, Amigo MC. The value of Jones criteria in the recognition of acute rheumatic fever fifty years later. Clin Exp Rheumatol 1994:12;355-356

48. Hermosillo AG, Ortiz R, Dábague J, Casanova JM, Martínez-Lavín M. Autonomic dysfunction in diffuse scleroderma vs CREST: an assesment by computerized heart rate variability. J Rheumatol 1994:21,1849-1854

49. Martínez-Lavín M, Mansilla J, Pineda C, Pijoán C. Evidence of hypertrophic osteoarthropathy in human skeletal remains from Prehispanic Mesoamerica. Ann Intern Med 1994:120:238-241

50. Martínez-Lavín M, Fonseca C, Amigo MC, Nava A, Reyes PA, Ruiz Arguelles A. Antiphospholipid syndrome in patients with cyanotic heart disease. Clin Exp Rheumatol 1995:13;489-491

51. Martínez-Lavín M, Mansilla J, Pineda C, Pijoán C. Ankylosing spondylitis is indigenous to Mesoamerica. J Rheumatol 1995;22:2327-2330

52. Martínez-Lavín M. Hypertrophic osteoarthropathy. Curr Opin Rheumatol 1997 ; 9 : 83-86

53. Martínez-Lavín M, Hermosillo AG, Mendoza C, Ortiz R, Cajigas JC, Pineda C, Nava A, Vallejo M. Orthostatic sympathetic derangement in individuals with fibromyalgia. J. Rheumatol 1997 ;24 : 714-718

54. Martínez-Lavín M, Buendía A, Pineda C. Hypertension in children. (letter) N Engl J Med 1997 ; 336 : 1975-76

55. Martínez-Lavín M, Vargas AS, Cabré C, Nava A, Amigo MC, Pineda C. Features of hypertrophic osteoarthropathy in patients with POEMS syndrome : a metaanalysis. J Rheumatol 1997 ;24 :2267-68

56. Martínez-Lavín M, Hermosillo AG. Orthostatic sympathetic derangement of baroreflex in patients with fibromyalgia (response to a letter) J Rheumatol 1998 ; 25 : 823-25

57. Pineda C, Mansilla C, Pijoán C, Fernandez S, Martínez-Lavín M. Radiographs of an ancient mortuary bundle supports theory for the new world origin of syphilis. Am J Roentgenol (AJR) 1998 ;171 :321-324

58. Martínez-Lavín M, Hermosillo AG, Rosas M, Soto ME. Circadian studies of autonomic nervous tone in patients with fibromyalgia. A heart rate variability analysis. Arthritis Rheum 1998 ; 41 :1966-1971

59. Pineda C, Gurza A, Rodriguez MA, Vazquez J, Castañon C, Silveira LH, Martínez-Lavín M. Revised diagnostic criteria for the Marfan syndrome. A clinical-radiographic assay. J Clin Rheumatol 1998; 278-286

60. Yamamoto-Furusho JK, Rodriguez-Reyna T, Zuñiga J, Vargas-Alarcón G, Martínez-Lavín M, Granados J. Immunogenetic study of 3 families with probands of primary hypertrophic osteoarthropathy. Clin Exp Rheumatol 1998 ;16 :629-30

61. Pineda C, Mansilla J, Pijoan C, Martínez-Lavín M. Origin of syphilis (response to a letter) Am J Roentgenol 1999;172:1138-39

62. Moreno-Sánchez R, Bravo C, Vásquez C, Ayala G, Silveira LH, Martínez-Lavín M. Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs. Study in mitochondria, submitochondrial particles, cells, and whole heart. Biochem Pharmacol 1999;57:743-752

63. Buendía A, Attié F, Martínez-Lavín M. The pericarditis-arthritis-camptodactyly syndrome. A under-recognized cause of pericardial constriction in children. Cardiol Young 1999

64. Martínez-Lavín M. Pineda C. Recognition of hypertrophic osteoarthropathy in skeletal remains (letter). J Rheumatol 1999; 26: 1640-42

65. Martínez-Lavín M, León A, Hermosillo AG, Pineda C, Amigo MC: The dysautonomia of fibromyalgia may simulate lupus. J Clin Rheumatol 1999; 5: 332-334

66. Silveira LH, Martínez-Lavín M, Pineda C, Fonseca MC, Navarro C, Nava A. Vascular endothelial growth factor and hypertrophic osteoarthropathy. Clin Exp Rheumatol 2000; 18: 57-62

67. Martinez-Lavin M, Hermosillo A G. Autonomic nervous system dysfunction may explain the multisystem features of fibromyalgia. Semin Arthritis Rheum 2000; 29: 197-199

68. Martinez-Lavin M, Amigo M C, Coindreau J, Canoso J. Fibromyalgia in Frida Kahlo's life and art. Arthritis Rheum 2000; 43: 708-709

69. Cantu C, Pineda C, Barinagarrementeria F, Salgado P, Gurza A, De Pablo P, Espinosa R, Martinez-Lavin M. Non-invasive cerebrovascular assessment of Takayasu's arteritis. Stroke 2000; 31: 2197-202

70. Martinez-Lavin M. Is fibromyalgia a generalized sympathetic dystrophy? Clin Exp Rheumatol 2001;19:1-3

71. Martínez-Lavín M. Overlap of fibromyalgia with other medical conditions. Curr Pain Headache Rep 2001;5:347-50

72. Martínez-Lavín M, Pineda C. Contribuciones de la Reumatología Mexicana al conocimiento médico. Osteoartropatía hipertrófica. Rev Mex Reumat 2001;16:223-26*

73. Martinez-Lavin M, Vidal M, Barbosa RE, Pineda C, Casanova JM, Nava A. Norepinephrine-evoked pain in fibromyalgia. A randomised pilot study (ISCRTN 70707830). BMC Musculoskel Disord 2002;3:2 (www.biomedcentral.com/1471-2474/3/2).

74. Martínez-Lavín M, Hermosillo AG. La fibromialgia y el sistema nervioso autónomo. Gac Med Mex 2002;138:55-56

75. Martinez-Lavin M. Autonomic nervous system in fibromyalgia. J Musculoskel Pain 2002 10:221-228

76. Martinez-Lavin M. Management of dysautonomia in fibromyalgia. Rheum Dis Clin North Am 2002 28:379-87

77. Martínez-Lavín M. A novel holistic explanation for the fibromyalgia enigma. Autonomic nervous system dysfunction. Fibromyalgia Frontiers 2002;10;3-6 ( http://www.fmpartnership.org/Lavin article.htm )

78. Amigo MC, Vidal M, Martínez-Lavín M. A minimally invasive lip biospy technique (letter). J Clin Rheumatol 2002;8:236

79. Martínez-Lavín M, López S, Medina M, Nava A. The use of the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) questionnaire in patients with fibromyalgia. Semin Arthritis Rheum 2003.

80. Kooh M, Martínez-Lavín M, Meza S, Martín-del-Campo A, Hermosillo Ag, Pineda C, Nava A, Amigo MC, Drucker-Colín R. Concurrent heart rate variability and polysomnography analyses in patients with fibromyalgia. Clin Exp Rheumatol 2003

* = Journals not included in Index Medicus

Thesis conduction

1. Dr. María Graciela Bobadilla Pichardo. Prevalence of hypertrophic osteoarthropathy in cyanotic congenital heart disease. Specialist in Rheumatology. UNAM. 1981.

2. Dr. Arnulfo Hernán Nava Zavala. Arterial hypertension in generalized lupus erythematosus. Specialist in Rheumatology. UNAM 1989.

3. Dr. Enrique Cuitláhuac Morales Villegas. Takayasu’s arteritis in children. Specialist in Cardiology. UNAM 1989

4. Dr. María Dolores Vázquez Abad. Presence of hypertrophic osteoarthropathy in patients with cyanotic congenital heart disease in relation to abnormal morphology of platelets. Specialist in Rheumatology. UNAM 1989

5. Dr. Gustavo Esteban Lugo Zamudio. Discrimination between infectious endocarditis and rheumatic fever reactivation. Specialist in Rheumatology., UNAM 1991

6. Dr. Janete Dábague Guzmán. Autonomic dysfunction in systemic sclerosis and CREST syndrome assessed by high resolution electrocardiogram. Specialist in Rheumatology. UNAM 1994

7. Dr. Rolando Espinosa Morales. Randomized double blind comparative study, of two months on the efficacy and tolerance to aceclofenac vs. piroxicam in the treatment of osteoarthritis of the knee. Specialist in Rheumatology. UNAM 1994

8. Dr. María del Carmen Fonseca Gutiérrez. Hepatic hypertrophic osteoarthropathy. Specialist in Rheumatology. UNAM 1995.

9. Dr. Rebeca Padilla Ortiz. Three month comparative study, at random, double blind, parallel, on the efficiency and tolerance to aceclofenac vs. tenoxicam in the treatment of rheumatoid arthritis. Specialist in Rheumatology. UNAM. 1995

10. Dr. Maria Cristina Mendoza Becerra. Spectral analysis of heart rate variability in fibromyalgia. Specialist in Rheumatology. UNAM 1997

11. Dr. Ana Sofía Vargas Avilés. A meta-analysis suggests that POEMS syndrome and hypertrophic osteoarthropathy share clinical and pathogenic features. Specialist in Rheumatology. UNAM 1997

12. Dr. Minh Kooh. Concurrent studies of autonomic nervous system function and polysomnography in patients with fibromyalgia. 1999. Thesis for Social Service in Investigation

13. Dr. Mirna Muñoz. Fatal familial insomnia as a model to study the pathogenesis of fibromyalgia/chronic fatigue. 1999. Specialist in Rheumatology. Ministry of Foreing Affairs.

Authoring of textbook chapters

1. Martínez-Lavín M. Hypertrophic osteoarthropathy. In: Schumacher R, Klippel J, Koopman G, eds. Primer in the Rheumatic diseases. The Arthritis Foundation. Atlanta. 1989, 1993,1997 and 2001 editions.

2. Martínez-Lavín M. Hypertrophic osteoarthropathy. In: Rheumatology. Gower Medical Ed. London UK. 1993,1997 and 2001 editions.

3. Vázquez-Abad D, Pineda C, Martínez-Lavín M. Hypertrophic Osteoarthropathy. In: Iglesias A Ed. Skeletal metabolic disease. National Health Institutes. Bogota Colombia 1993.

4. Martínez-Lavín M. Hypertrophic Osteoarthropathy. In: Pascual E, Rodríguez-Valverde V, carbonell J, Gómez-Reino J eds. Rheumatology. Locomotive and connective tissue disease. ARAN Ed. Madrid. 1998

5. Martínez-Lavín M: Backache and regional painful syndromes. In: Uribe M: Ed. Treatise on Internal Medicine. Ed. Panamericana Mexico D.F. 1995.